Integrin β4 as a Potential Diagnostic and Therapeutic Tumor Marker
WEBAug 12, 2021 · Integrin β4 (ITGβ4) is a class of transmembrane adhesion molecules composed of hemidesmosomes (HDs). Its unique long intracellular domain provides intricate signal transduction functions. These signal transduction effects are especially prominent in tumors.
Proteolytic cleavage of the integrin beta 4 subunit - PubMed
WEBThe cleavage of beta 4 is catalyzed by a calpain-like enzyme because (i) it requires calcium, (ii) it is mimicked by purified milli-calpain, and (iii) it is inhibited by several calpain inhibitors including the calpain-specific inhibitor calpastatin.
Granzyme B is elevated in autoimmune blistering diseases and cleaves ...
WEBJun 26, 2018 · Both α6 and β4 integrin sub-units were cleaved by GzmB (Fig. 2a,b); α6 integrin was detected at 150 kDa with fragments at ~20, 25, and 37 kDa, whereas cleavage of β4 integrin ectodomain...
Targeting integrin pathways: mechanisms and advances in …
WEBJan 2, 2023 · Integrins are considered the main cell-adhesion transmembrane receptors that play multifaceted roles as extracellular matrix (ECM)-cytoskeletal linkers and transducers in biochemical and mechanical...
Integrins as the pivotal regulators of cisplatin response in tumor ...
WEBMay 13, 2024 · Integrin α6β4 promotes p53 to cause Akt cleavage, p21 over-expression, and apoptosis [135,136,137]. 53BP1 is an important downstream effector of DNA-PK and p53 that can modify cisplatin sensitivity and is used for deciding between NHEJ and HR [138,139,140]. DNA-PK and p53 mutations are significantly involved in integrin α6β4-mediated CDDP ...
Adhesion signaling – crosstalk between integrins, Src and Rho
WEBApr 15, 2009 · In cells that are adhering to fibronectin, p190RhoGAP regulation can involve extensive cooperation between different classes of receptors: engagement of integrin α5β1 stimulates Src-mediated p190RhoGAP tyrosine phosphorylation, whereas binding of the proteoglycan receptor syndecan-4 is required in some cell …
Proteolytic Cleavage of the Integrin β4 Subunit - ScienceDirect
WEBMay 1, 1994 · The integrin β 4 subunit often undergoes proteolytic cleavage within its long cytoplasmic tail to yield a characteristic protein pattern of 205, 165, and 125 kDa. The results in this study suggest that β 4 cleavage often occurs during or after cell lysis, where it was readily inhibitable by calcium chelators (EDTA, EGTA) and inhibitors of ...
Integrins in cancer: Emerging mechanisms and ... - ScienceDirect
WEBJul 1, 2023 · Integrins are vital surface adhesion receptors that mediate interactions between the extracellular matrix (ECM) and cells and are essential for cell migration and the maintenance of tissue homeostasis. Aberrant integrin activation promotes initial tumor formation, growth, and metastasis.
WEBcell growth by integrins is important in elucidating their effects on tumor progression. One of the major events in integrin signaling is integrin binding to extracellular ligands.
Proteolytic cleavage of the integrin beta 4 subunit. - Abstract ...
WEBMay 1, 1994 · The cleavage of beta 4 is catalyzed by a calpain-like enzyme because (i) it requires calcium, (ii) it is mimicked by purified milli-calpain, and (iii) it is inhibited by several calpain inhibitors including the calpain-specific inhibitor calpastatin.
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