The Big Ten on CBS will feature a top-20 matchup in Week 4 as the No. 18 Michigan Wolverines host the No. 11 USC Trojans on Saturday for a 3:30 p.m. ET kickoff. The defending national champions were blown out at home by Texas but could get themselves back into the College Football Playoff mix with a run to the Big Ten Championship Game.

Here are the five biggest "must-watch" games on the docket for this weekend. While this game may not be the most exciting, Arch Manning is scheduled to make his first start for the Longhorns. That alone makes this game a must-watch on the schedule to see how he can perform.

Florida Gators vs Mississippi State Bulldogs picks, predictions, odds, TV channel, streaming for Week 4 college football game on Saturday, Sept. 21.